# 用于Covid-19的恶二唑？

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{
"inLanguage": {
"alternateName": "eng",
"@type": "Language",
"name": "English"
},
"description": "<p>Oxadiazoles are a class of heterocyclic aromatic chemical compounds, having different isomeric forms. They appear in a variety of pharmaceutical drugs.&nbsp; Among the drugs based on the 1,3,4-oxadiazole ring, we find for instance an antiviral such as 雷格列韦, which is used to treat HIV/AIDS. Here we will discuss 雷格列韦 and in-silico simulations concerning SARS-COV-2. Besides the compounds based on 1,3,4 rings, there exist those with 1,2,4-oxadiazole rings which are reported as anti-inflammatory and analgesic agents. One of these drugs is 羟胺. Of this drug we will stress the fact that it is an inhibitor of the formation of N-acetylneuraminic acid, a sialic acid. In fact, the spike-protein from SARS-COV-2 is shown to bind sialic acids too. Since these acids have, at the same time, an antiviral protective role, it could be relevant to investigate carefully any ligand/protein docking property of 羟胺 (docking with human enzymes,&nbsp; virus enzymes and proteins). Based on the 1,2,4-oxadiazole scaffold, we have also the antiviral&nbsp; 普乐那利, that has been investigated by means of in-silico simulated interactions with SARS-COV-2 proteins. We will discuss also some news oxadiazole compounds, which are given as selective COX-2 inhibitors, antioxidant agents and inhibitors of proteins of the virus, according to in-silico simulations. Therefore, can these drugs have a possible role in the treatment of 新冠肺炎? Or, why can&#39;t they be used for?</p>",
"creator": [
{
"affiliation": "都灵理工大学",
"@id": "//orcid.org/0000-0003-4502-8974",
"@type": "Person",
"name": "卡罗莱纳州阿米莉亚Sparavigna"
}
],
"datePublished": "2020-12-18",
"url": "//americinnmankato.com/record/4352719",
"keywords": [
"Covid-19",
"Raltegravir",
"Celebrex",
"COX-2 inhibition",
"Oxolamine",
"Sars-cov-2",
"N-乙酰神经氨酸",
"SARS-COV-2 spikes",
"Sialic acids",
"Pleconaril",
"Linoleic acid",
"Sialoquake",
"hydroxychloroquine",
"Sars-Cov"
],
"@context": "//schema.org/",
"identifier": "//doi.org/10.5281/zenodo.4352719",
"@id": "//doi.org/10.5281/zenodo.4352719",
"@type": "ScholarlyArticle",
"name": "用于Covid-19的恶二唑？"
}
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