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# 新冠肺炎的牛奶唑？

Sparavigna，Amelia Carolina

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{
"publisher": "Zenodo",
"DOI": "10.5281 / zenodo.4327542",
"language": "eng",
"title": "Covid-19的牛奶唑？",
"issued": {
"date-parts": [
[
2020,
12,
16
]
]
},
"abstract": "<p>Oxadiazoles are a class of heterocyclic aromatic chemical compounds, having different isomeric forms. They appear in a variety of pharmaceutical drugs.&nbsp; Among the drugs based on the 1,3,4-oxadiazole ring, we find for instance an antiviral such as Raltegravir, which is used to treat HIV/AIDS. Here we will discuss Raltegravir and in-silico simulations concerning SARS-COV-2. Besides the compounds based on 1,3,4 rings, there exist those with 1,2,4-oxadiazole rings which are reported as anti-inflammatory and analgesic agents. One of these drugs is Oxolamine. Of this drug we will stress the fact that it is an inhibitor of the formation of N-acetylneuraminic acid, a sialic acid. This could be an interesting fact, since the spike-protein from SARS-COV-2 is shown to bind sialic acids too. Based on the 1,2,4-oxadiazole scaffold, we have also the antiviral&nbsp; Pleconaril, that has been investigated by means of in-silico simulated interactions with SARS-COV-2 proteins. We will discuss also some news oxadiazole compounds, which are given as selective COX-2 inhibitors, antioxidant agents and inhibitors of proteins of the virus, according to in-silico simulations. Therefore, can these drugs have a possible role in the treatment of Covid-19? Or, why can&#39;t they be used for?</p>",
"author": [
{
"family": "Sparavigna，Amelia Carolina"
}
],
"note": "Let us stress that the main target of SARS-COV-2 is considered the ACE2 receptor. Then, is the sialic acid supporting the virus to enter the cell? A study,  10.1021/acscentsci.0c00855, that used  a glyco-nanoparticle platform, reported the discovery that N-乙酰基神经氨酸 has affinity toward the SARS-COV-2 spike glycoprotein, that is a glycan-binding function. However, a recent study, 10.1016/j.scib.2021.01.010, which has investigated the binding of the spikes of the virus by means of micro-arrays, tells that no binding with sialic acid residues was detected. --- see PLEASE the new version.",
"type": "article",
"id": "4327542"
}
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